Adaptive Amplification and Point Mutation Are Independent Mechanisms: Evidence for Various Stress-Inducible Mutation Mechanisms
نویسندگان
چکیده
منابع مشابه
Adaptive Amplification and Point Mutation Are Independent Mechanisms: Evidence for Various Stress-Inducible Mutation Mechanisms
"Adaptive mutation" denotes a collection of processes in which cells respond to growth-limiting environments by producing compensatory mutants that grow well, apparently violating fundamental principles of evolution. In a well-studied model, starvation of stationary-phase lac(-)Escherichia coli cells on lactose medium induces Lac(+)revertants at higher frequencies than predicted by usual mutati...
متن کاملRebuttal: adaptive point mutation (Rosenberg and Hastings).
The Rosenberg-Hastings paper (4) defends a model much like that of Foster (1) and argues that the observed mutagenesis contradicts predictions of the amplification model. On the contrary, amplification indirectly causes weak mutagenesis and allows that mutagenesis to have a detectable effect on lac reversion. However, this mutagenesis is a minor side effect that is neither sufficient nor necess...
متن کاملThe amplification model for adaptive mutation: simulations and analysis.
It has been proposed that the lac revertants arising under selective conditions in the Cairns experiment do not arise by stress-induced mutagenesis of stationary phase cells as has been previously assumed. Instead, these revertants may arise within growing clones initiated by cells with a preexisting duplication of the weakly functional lac allele used in this experiment. It is proposed that sp...
متن کاملOxidative DNA damage: mechanisms, mutation, and disease.
Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a propensity for increased levels following toxic insult. Although more than 20 base lesions have been identified, only a fraction of these have received appreciable study, most notably 8-oxo-2'deoxyguanosine. This lesion has been the focus of intense research interest and been ascribed much importance, largely to th...
متن کاملPathogenic Mechanisms of the Arctic Alzheimer Mutation
The Arctic mutation interferes with processing of the amyloid precursor protein. The Arctic Alzheimer mutation favors intracellular Aȕ production by making APP less available to Į-secretase. Journal of Neurochemistry, in press.ȕ oligomers are inefficiently measured by enzyme-linked immunosorbent assay. and Johansson AS. Docosahexaenoic acid stimulates non-amyloidogenic APP processing resulting ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Biology
سال: 2004
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.0020399